Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. [5]
| PARP14 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4 |
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| Identifiers |
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| Aliases | PARP14, ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14 |
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| External IDs | OMIM: 610028 MGI: 1919489 HomoloGene: 19697 GeneCards: PARP14 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 3 (human)[1] |
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| | Band | 3q21.1 | Start | 122,680,839 bp[1] |
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| End | 122,730,840 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 16 (mouse)[2] |
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| | Band | 16|16 B3 | Start | 35,832,874 bp[2] |
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| End | 35,871,544 bp[2] |
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| Gene ontology |
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| Molecular function | • transferase activity
• transferase activity, transferring glycosyl groups
• RNA binding
• GO:0001948 protein binding
• NAD+ binding
• NAD+ ADP-ribosyltransferase activity
• enzyme binding
• protein ADP-ribosylase activity
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| Cellular component | • membrane
• cell nucleus
• cytosol
• cytoplasm
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| Biological process | • regulation of transcription, DNA-templated
• transcription, DNA-templated
• protein poly-ADP-ribosylation
• protein ADP-ribosylation
• negative regulation of gene expression
• positive regulation of tyrosine phosphorylation of STAT protein
• negative regulation of tyrosine phosphorylation of STAT protein
• negative regulation of interferon-gamma-mediated signaling pathway
• positive regulation of interleukin-4-mediated signaling pathway
• immune system process
• innate immune system
• protein mono-ADP-ribosylation
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 3: 122.68 – 122.73 Mb | Chr 16: 35.83 – 35.87 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditPoly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).
